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Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, E H | - |
dc.contributor.author | Moon, K C | - |
dc.contributor.author | Lee, E Y | - |
dc.contributor.author | Lee, Y J | - |
dc.contributor.author | Lee, E B | - |
dc.contributor.author | Ahn, C | - |
dc.contributor.author | Song, Y W | - |
dc.date.accessioned | 2010-07-04T23:48:29Z | - |
dc.date.available | 2010-07-04T23:48:29Z | - |
dc.date.issued | 2008-12-17 | - |
dc.identifier.citation | Lupus. 2009; 18(1): 22-28 | en |
dc.identifier.issn | 0961-2033 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19074165 | - |
dc.identifier.uri | http://lup.sagepub.com/cgi/reprint/18/1/22.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68210 | - |
dc.description.abstract | The aim of the study is to characterize the expression pattern of galectin-3 (Gal-3) in renal tissues of patients with systemic lupus erythematosus (SLE) nephritis and to determine whether tissue and serum Gal-3 are associated with SLE nephritis. Gal-3 expressions were examined with immunohistochemistry in renal biopsy specimens of 88 patients with SLE nephritis and in five normal specimens. Activity and chronicity indexes and glomerular Gal-3 expressions were analysed in each specimen. Serum Gal-3 levels were measured using enzyme-linked immunosorbent assays in 20 patients with SLE, including 11 with nephritis, and in 50 healthy controls. Glomerular Gal-3 expression was observed in 81.8% (72/88) of patients with SLE nephritis but not in 5 controls. Gal-3 staining was attributed mainly to its cellular expression rather than its deposition, and Gal-3 expression levels were correlated with histologic activity indexes, anti-dsDNA titers, and complement 3 and 4 levels. Serum Gal-3 levels were higher in patients with SLE, particularly in those with nephritis, than in healthy controls, and correlated with anti-dsDNA titers. In conclusion, glomerular Gal-3 expression in renal tissue and serum Gal-3 levels were elevated in patients with SLE nephritis versus healthy controls; moreover, they reflected disease activity. These findings suggest that Gal-3 might contribute to the inflammatory process in SLE. | en |
dc.description.sponsorship | This work was supported by the Korea Science and
Engineering Foundation (KOSEF) through the National Research Lab funded by the Korean Ministry of Science and Technology (#ROA- 2004-000-10296-0). | en |
dc.language.iso | en | en |
dc.publisher | SAGE Publications | en |
dc.subject | Adult | en |
dc.subject | Antibodies, Antinuclear | en |
dc.subject | Complement C3/metabolism | en |
dc.subject | Complement C4/metabolism | en |
dc.subject | DNA/metabolism | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Female | en |
dc.subject | Galectin 3/*genetics/metabolism | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Kidney Glomerulus/*metabolism/pathology | en |
dc.subject | Lupus Erythematosus, Systemic/*genetics | en |
dc.subject | Lupus Nephritis/*genetics/metabolism | en |
dc.subject | Male | en |
dc.subject | Young Adult | en |
dc.subject | Gene Expression | - |
dc.title | Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis | en |
dc.type | Article | en |
dc.identifier.doi | 10.1177/0961203308094361 | - |
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