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Renal expression of galectin-3 in systemic lupus erythematosus patients with nephritis

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dc.contributor.authorKang, E H-
dc.contributor.authorMoon, K C-
dc.contributor.authorLee, E Y-
dc.contributor.authorLee, Y J-
dc.contributor.authorLee, E B-
dc.contributor.authorAhn, C-
dc.contributor.authorSong, Y W-
dc.date.accessioned2010-07-04T23:48:29Z-
dc.date.available2010-07-04T23:48:29Z-
dc.date.issued2008-12-17-
dc.identifier.citationLupus. 2009; 18(1): 22-28en
dc.identifier.issn0961-2033 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19074165-
dc.identifier.urihttp://lup.sagepub.com/cgi/reprint/18/1/22.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/68210-
dc.description.abstractThe aim of the study is to characterize the expression pattern of galectin-3 (Gal-3) in renal tissues of patients with systemic lupus erythematosus (SLE) nephritis and to determine whether tissue and serum Gal-3 are associated with SLE nephritis. Gal-3 expressions were examined with immunohistochemistry in renal biopsy specimens of 88 patients with SLE nephritis and in five normal specimens. Activity and chronicity indexes and glomerular Gal-3 expressions were analysed in each specimen. Serum Gal-3 levels were measured using enzyme-linked immunosorbent assays in 20 patients with SLE, including 11 with nephritis, and in 50 healthy controls. Glomerular Gal-3 expression was observed in 81.8% (72/88) of patients with SLE nephritis but not in 5 controls. Gal-3 staining was attributed mainly to its cellular expression rather than its deposition, and Gal-3 expression levels were correlated with histologic activity indexes, anti-dsDNA titers, and complement 3 and 4 levels. Serum Gal-3 levels were higher in patients with SLE, particularly in those with nephritis, than in healthy controls, and correlated with anti-dsDNA titers. In conclusion, glomerular Gal-3 expression in renal tissue and serum Gal-3 levels were elevated in patients with SLE nephritis versus healthy controls; moreover, they reflected disease activity. These findings suggest that Gal-3 might contribute to the inflammatory process in SLE.en
dc.description.sponsorshipThis work was supported by the Korea Science and
Engineering Foundation (KOSEF) through the
National Research Lab funded by the Korean
Ministry of Science and Technology (#ROA-
2004-000-10296-0).
en
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.subjectAdulten
dc.subjectAntibodies, Antinuclearen
dc.subjectComplement C3/metabolismen
dc.subjectComplement C4/metabolismen
dc.subjectDNA/metabolismen
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFemaleen
dc.subjectGalectin 3/*genetics/metabolismen
dc.subject*Gene Expressionen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKidney Glomerulus/*metabolism/pathologyen
dc.subjectLupus Erythematosus, Systemic/*geneticsen
dc.subjectLupus Nephritis/*genetics/metabolismen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.titleRenal expression of galectin-3 in systemic lupus erythematosus patients with nephritisen
dc.typeArticleen
dc.identifier.doi10.1177/0961203308094361-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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