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Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter

Cited 31 time in Web of Science Cited 34 time in Scopus
Authors
Lee, Byung Yang; Lee, Dong Joon; Lee, Minbaek; Lee, Joohyung; Cheon, Jun-Ho; Cho, Eunju; Lee, Hyunjoong; Chung, In-Young; Park, Young June; Kim, Suhwan; Hong, Seunghun; Seo, Sung Min
Issue Date
2010-04
Publisher
Royal Society of Chemistry
Citation
Lab on a Chip, 2010, 10, 894-898
Keywords
Biosensor systemCMOS
Abstract
We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of
a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing
circuits in a single chip, which was made possible by combining several technological breakthroughs
such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNTbased
sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia,
a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors,
modulated the conductance signals to the CNT-based sensors. This is a major technological
advancement in the integration of CNT-based sensors with microelectronics, and this chip can be
readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC
systems for neural networks.
ISSN
1473-0197
Language
English
URI
http://hdl.handle.net/10371/68316
DOI
https://doi.org/10.1039/b916975j
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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