S-Space College of Medicine/School of Medicine (의과대학/대학원) Neurosurgery (신경외과학전공) Journal Papers (저널논문_신경외과학전공)
Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus
- Jeon, Gye Sun; Park, Sung Kyung; Park, Sang Wook; Kim, Dong Woon; Chung, Chun Kee; Cho, Sa Sun
- Issue Date
- Springer Verlag
- Neurochem Res. 33(1):179-184
- Animals; Blotting, Western; Hippocampus/*drug effects/metabolism; Immunohistochemistry; Interleukin-18/*metabolism; Kainic Acid/*toxicity; Male; Mice; Mice, Inbred ICR; Neuroglia/*metabolism; Receptors, Interleukin-18/*metabolism
- Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus.
- 0364-3190 (Print)
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