Browse

The efficacy of combined estrogen and buspirone treatment in olivopontocerebellar atrophy

Cited 14 time in Web of Science Cited 20 time in Scopus
Authors
Heo, Jae-Hyeok; Lee, Soon-Tae; Chu, Kon; Kim, Manho
Issue Date
2008-05-10
Publisher
Elsevier
Citation
J Neurol Sci. 2008;271(1-2):87-90
Keywords
AdultBuspirone/*therapeutic useDrug Therapy, CombinationEstrogens/*therapeutic useEvaluation Studies as TopicFemaleFollow-Up StudiesHumansMaleMiddle AgedOlivopontocerebellar Atrophies/*drug therapySerotonin Agonists/*therapeutic useSeverity of Illness Index
Abstract
BACKGROUND: Olivopontocerebellar atrophy (OPCA) is a chronic neurodegenerative disease with symptoms of cerebellar ataxia, parkinsonism, autonomic disturbances and ophthalmoplegia. Buspirone, a 5-HT1(A) agonist could constitute a symptomatic improvement in cerebellar dysfunction whereas estrogen has been investigated for neuroprotection. We conducted an open-labeled pilot trial to assess the efficacy of estrogen with buspirone treatment. PATIENTS AND METHODS: Eighteen patients (7 male and 11 female) with OPCA were randomized into the buspirone (15 mg/day, n=9), or the combined treatment group (estrogen, 0.625 mg/d plus buspirone, n=9). For the clinical rating, International Cooperative Ataxia Rating Scale (ICARS) was used and dysarthria, gaze evoked nystagmus, finger to nose, pronation-supination alternating movement, knee-tibia test, and gait speed were evaluated for 12 months. RESULTS: Buspirone-treated group showed improvements in finger to nose and pronation-supination alternating movement test (p=0.046 and p=0.025, respectively). The combination group (Estrogen+buspirone), however, showed no improvement in cerebellar sub-scales compared to the baseline. CONCLUSIONS: Buspirone treatment showed feasible efficacies for OPCA, while the combined treatment of estrogen and buspirone failed to improve, suggesting estrogen may not have further benefit in cerebellar dysfunction.
ISSN
0022-510X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18466925

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T06-4SFR7XW-2-1&_cdi=4854&_user=168665&_orig=search&_coverDate=08%2F15%2F2008&_sk=997289998&view=c&wchp=dGLzVtb-zSkzk&md5=99f86ffeae71150d9b720e8ba706da0c&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68465
DOI
https://doi.org/10.1016/j.jns.2008.03.016
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse