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The efficacy of combined estrogen and buspirone treatment in olivopontocerebellar atrophy
Cited 17 time in
Web of Science
Cited 23 time in Scopus
- Authors
- Issue Date
- 2008-05-10
- Publisher
- Elsevier
- Citation
- J Neurol Sci. 2008;271(1-2):87-90
- Keywords
- Adult ; Buspirone/*therapeutic use ; Drug Therapy, Combination ; Estrogens/*therapeutic use ; Evaluation Studies as Topic ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Olivopontocerebellar Atrophies/*drug therapy ; Serotonin Agonists/*therapeutic use ; Severity of Illness Index
- Abstract
- BACKGROUND: Olivopontocerebellar atrophy (OPCA) is a chronic neurodegenerative disease with symptoms of cerebellar ataxia, parkinsonism, autonomic disturbances and ophthalmoplegia. Buspirone, a 5-HT1(A) agonist could constitute a symptomatic improvement in cerebellar dysfunction whereas estrogen has been investigated for neuroprotection. We conducted an open-labeled pilot trial to assess the efficacy of estrogen with buspirone treatment. PATIENTS AND METHODS: Eighteen patients (7 male and 11 female) with OPCA were randomized into the buspirone (15 mg/day, n=9), or the combined treatment group (estrogen, 0.625 mg/d plus buspirone, n=9). For the clinical rating, International Cooperative Ataxia Rating Scale (ICARS) was used and dysarthria, gaze evoked nystagmus, finger to nose, pronation-supination alternating movement, knee-tibia test, and gait speed were evaluated for 12 months. RESULTS: Buspirone-treated group showed improvements in finger to nose and pronation-supination alternating movement test (p=0.046 and p=0.025, respectively). The combination group (Estrogen+buspirone), however, showed no improvement in cerebellar sub-scales compared to the baseline. CONCLUSIONS: Buspirone treatment showed feasible efficacies for OPCA, while the combined treatment of estrogen and buspirone failed to improve, suggesting estrogen may not have further benefit in cerebellar dysfunction.
- ISSN
- 0022-510X (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18466925
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T06-4SFR7XW-2-1&_cdi=4854&_user=168665&_orig=search&_coverDate=08%2F15%2F2008&_sk=997289998&view=c&wchp=dGLzVtb-zSkzk&md5=99f86ffeae71150d9b720e8ba706da0c&ie=/sdarticle.pdf
https://hdl.handle.net/10371/68465
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