S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
The efficacy of combined estrogen and buspirone treatment in olivopontocerebellar atrophy
- Heo, Jae-Hyeok; Lee, Soon-Tae; Chu, Kon; Kim, Manho
- Issue Date
- J Neurol Sci. 2008;271(1-2):87-90
- Adult; Buspirone/*therapeutic use; Drug Therapy, Combination; Estrogens/*therapeutic use; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Olivopontocerebellar Atrophies/*drug therapy; Serotonin Agonists/*therapeutic use; Severity of Illness Index
- BACKGROUND: Olivopontocerebellar atrophy (OPCA) is a chronic neurodegenerative disease with symptoms of cerebellar ataxia, parkinsonism, autonomic disturbances and ophthalmoplegia. Buspirone, a 5-HT1(A) agonist could constitute a symptomatic improvement in cerebellar dysfunction whereas estrogen has been investigated for neuroprotection. We conducted an open-labeled pilot trial to assess the efficacy of estrogen with buspirone treatment. PATIENTS AND METHODS: Eighteen patients (7 male and 11 female) with OPCA were randomized into the buspirone (15 mg/day, n=9), or the combined treatment group (estrogen, 0.625 mg/d plus buspirone, n=9). For the clinical rating, International Cooperative Ataxia Rating Scale (ICARS) was used and dysarthria, gaze evoked nystagmus, finger to nose, pronation-supination alternating movement, knee-tibia test, and gait speed were evaluated for 12 months. RESULTS: Buspirone-treated group showed improvements in finger to nose and pronation-supination alternating movement test (p=0.046 and p=0.025, respectively). The combination group (Estrogen+buspirone), however, showed no improvement in cerebellar sub-scales compared to the baseline. CONCLUSIONS: Buspirone treatment showed feasible efficacies for OPCA, while the combined treatment of estrogen and buspirone failed to improve, suggesting estrogen may not have further benefit in cerebellar dysfunction.
- 0022-510X (Print)
- Files in This Item: There are no files associated with this item.