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Intracoronary continuous adenosine infusion

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Koo, Bon-Kwon; Kim, Cheol-Ho; Na, Sang-Hun; Youn, Tae-Jin; Chae, In-Ho; Choi, Dong-Ju; Kim, Hyo-Soo; Lee, Myoung-Mook; Oh, Byung-Hee; Park, Young-Bae; Choi, Yun-Shik; Tahk, Seung-Jae

Issue Date
The Japanese Circulation Society
Circ J. 2005;69(8): 908-912
Adenosine/*administration & dosageAgedBlood Flow Velocity/drug effectsCoronary Circulation/*drug effectsFemaleHumansHyperemia/*chemically inducedInfusions, Intra-ArterialMaleMiddle AgedCoronary Stenosis/drug therapy
BACKGROUND: Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. METHODS AND RESULTS: Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 microg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 microg/min) with IC bolus injection (40, 80 microg) and intravenous (IV) infusion (140 microg x kg (-1) x min(-1)) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p = 0.06). In the phase II study, FFR after an IC bolus injection (0.83+/-0.06) was significantly higher than with IV (0.79+/-0.07) or IC (0.78+/-0.09) infusion (p < 0.01). However, no difference in FFR was observed for IC and IV infusions. CONCLUSION: IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement.
1346-9843 (Print)
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