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Gene expression patterns in glucose-stimulated podocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Yang, Sanghwa | - |
dc.contributor.author | Jung, Dong Sub | - |
dc.contributor.author | Li, Jin Ji | - |
dc.contributor.author | Kim, Jin Ju | - |
dc.contributor.author | Kwak, Seung Jae | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Moon, Sung Jin | - |
dc.contributor.author | Lee, Jung Eun | - |
dc.contributor.author | Han, Dae-Suk | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.date.accessioned | 2010-07-08 | - |
dc.date.available | 2010-07-08 | - |
dc.date.issued | 2008-04-09 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 370 (2008) 514-518 | en |
dc.identifier.issn | 1090-2104 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18395008 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4S6GP8M-9-D&_cdi=6713&_user=168665&_orig=search&_coverDate=06%2F06%2F2008&_sk=996299996&view=c&wchp=dGLbVzW-zSkWA&md5=8989f8009a4144d0b3ac3f83c4e948a0&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68492 | - |
dc.description.abstract | To explore the mechanisms of podocyte injury under diabetic conditions, we performed an expression profile in glucose-stimulated podocytes. Differential gene expression profiles between conditionally immortalized mouse podocytes cultured in medium containing 5.6 and 30 mM glucose were measured with oligonucleotide microarrays. Of the genes identified, heme oxygenase-1, vascular endothelial growth factor-A, and thrombospondin-1 showed a consistently increased pattern, whereas angiotensin-converting enzyme-2 and peroxisomal proliferator activator receptor-gamma were down-regulated. These results were validated using real-time PCR and western blotting in podocytes, and with immunohistochemistry on renal tissues from streptozotocin-induced diabetic rats. Not only is this the first report of gene expression profiling of podocyte injury under diabetic conditions, but the identified genes are promising targets for future diabetes research. | en |
dc.description.sponsorship | This work was supported in part by the Brain Korea 21 Project
for Medical Sciences, Yonsei University. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Blotting, Western | en |
dc.subject | Cells, Cultured | en |
dc.subject | Diabetic Nephropathies/*genetics/pathology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Gene Expression/drug effects | en |
dc.subject | Glucose/*metabolism/pharmacology | en |
dc.subject | Mice | en |
dc.subject | Podocytes/drug effects/*metabolism/pathology | en |
dc.subject | Rats | en |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | en |
dc.subject | Gene Expression Profiling | - |
dc.title | Gene expression patterns in glucose-stimulated podocytes | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한승혁 | - |
dc.contributor.AlternativeAuthor | 양상화 | - |
dc.contributor.AlternativeAuthor | 정동섭 | - |
dc.contributor.AlternativeAuthor | 김진주 | - |
dc.contributor.AlternativeAuthor | 곽승재 | - |
dc.contributor.AlternativeAuthor | 김동기 | - |
dc.contributor.AlternativeAuthor | 문성진 | - |
dc.contributor.AlternativeAuthor | 이정은 | - |
dc.contributor.AlternativeAuthor | 한대석 | - |
dc.contributor.AlternativeAuthor | 강신욱 | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.03.121 | - |
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