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Gene expression patterns in glucose-stimulated podocytes

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dc.contributor.authorHan, Seung Hyeok-
dc.contributor.authorYang, Sanghwa-
dc.contributor.authorJung, Dong Sub-
dc.contributor.authorLi, Jin Ji-
dc.contributor.authorKim, Jin Ju-
dc.contributor.authorKwak, Seung Jae-
dc.contributor.authorKim, Dong Ki-
dc.contributor.authorMoon, Sung Jin-
dc.contributor.authorLee, Jung Eun-
dc.contributor.authorHan, Dae-Suk-
dc.contributor.authorKang, Shin-Wook-
dc.date.accessioned2010-07-08-
dc.date.available2010-07-08-
dc.date.issued2008-04-09-
dc.identifier.citationBiochem Biophys Res Commun. 370 (2008) 514-518en
dc.identifier.issn1090-2104 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18395008-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4S6GP8M-9-D&_cdi=6713&_user=168665&_orig=search&_coverDate=06%2F06%2F2008&_sk=996299996&view=c&wchp=dGLbVzW-zSkWA&md5=8989f8009a4144d0b3ac3f83c4e948a0&ie=/sdarticle.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/68492-
dc.description.abstractTo explore the mechanisms of podocyte injury under diabetic conditions, we performed an expression profile in glucose-stimulated podocytes. Differential gene expression profiles between conditionally immortalized mouse podocytes cultured in medium containing 5.6 and 30 mM glucose were measured with oligonucleotide microarrays. Of the genes identified, heme oxygenase-1, vascular endothelial growth factor-A, and thrombospondin-1 showed a consistently increased pattern, whereas angiotensin-converting enzyme-2 and peroxisomal proliferator activator receptor-gamma were down-regulated. These results were validated using real-time PCR and western blotting in podocytes, and with immunohistochemistry on renal tissues from streptozotocin-induced diabetic rats. Not only is this the first report of gene expression profiling of podocyte injury under diabetic conditions, but the identified genes are promising targets for future diabetes research.en
dc.description.sponsorshipThis work was supported in part by the Brain Korea 21 Project
for Medical Sciences, Yonsei University.
en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAnimalsen
dc.subjectBlotting, Westernen
dc.subjectCells, Cultureden
dc.subjectDiabetic Nephropathies/*genetics/pathologyen
dc.subjectDisease Models, Animalen
dc.subjectGene Expression/drug effectsen
dc.subject*Gene Expression Profilingen
dc.subjectGlucose/*metabolism/pharmacologyen
dc.subjectMiceen
dc.subjectPodocytes/drug effects/*metabolism/pathologyen
dc.subjectRatsen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.titleGene expression patterns in glucose-stimulated podocytesen
dc.typeArticleen
dc.contributor.AlternativeAuthor한승혁-
dc.contributor.AlternativeAuthor양상화-
dc.contributor.AlternativeAuthor정동섭-
dc.contributor.AlternativeAuthor김진주-
dc.contributor.AlternativeAuthor곽승재-
dc.contributor.AlternativeAuthor김동기-
dc.contributor.AlternativeAuthor문성진-
dc.contributor.AlternativeAuthor이정은-
dc.contributor.AlternativeAuthor한대석-
dc.contributor.AlternativeAuthor강신욱-
dc.identifier.doi10.1016/j.bbrc.2008.03.121-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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