Fibronectin fragment promotes osteoblast-associated gene expression and biological activity of human osteoblast-like cell

Abstract

A fibronectin fragment, which spans from the ninth to tenth type III domain, showed >95% biological activity in promoting osteoblast adhesion, proliferation and differentiation level compared with those of native fibronectin (FN) molecule. This suggests that the FN type III ninth-tenth domain fragment serves a good substitute for native FN in biomimetic application for osteogenesis.