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Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model

Cited 33 time in Web of Science Cited 34 time in Scopus
Authors
Chang, Sun-Hwa; Choi, Youngnim; Park, Jung-Ae; Jung, Dong-Sik; Shin, Jieun; Yang, Ji-Hyun; Ko, Seon-Yle; Kim, Se-Won; Kim, Jung-Keun
Issue Date
2007-12
Publisher
Elsevier
Citation
Clin Nutr. 2007;26(6):785-791
Keywords
Panax notoginsengArthritisTNF-αNF-κBMAPK
Abstract
Background & aims
Although there has been some success with protein-based anti-tumor necrosis factor α (TNF-α) therapeutics, the problems associated with protein-based drugs demand alternative approaches. We screened various herbal extracts for their ability to inhibit TNF-α secretions and found that BT-201, an n-butanol extract of Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) has such an ability.

Methods
The purpose of this study has been to evaluate the anti-inflammatory and anti-rheumatic effects of BT-201. The anti-inflammatory effects were evaluated by measuring the effects of BT-201 on the production of TNF-α, interleukin (IL)-1β, inducible nitric oxide (iNO), and matrix metalloproteinase-13 (MMP-13), in vitro. The anti-rheumatic effects were evaluated by treating mice with collagen-induced arthritis (CIA) using a daily oral administration of BT-201 at 15 mg/kg/day. In addition, the effects on NF-κB and mitogen-activated protein kinase (MAPK) pathways were evaluated by Western blotting using phospho-specific antibodies.

Results
BT-201 significantly inhibited all the inflammatory parameters evaluated in vitro and delayed the onset and progression of CIA. BT-201 inhibited the activation of NF-κB, ERK, p38, and JNK pathways.

Conclusions
Our results demonstrated that BT-201 can modulate various aspects of inflammation in vitro and that it has disease-modifying, anti-rheumatic effects in vivo, suggesting that it can be a potential alternative to the current anti-TNF-α therapeutics for rheumatoid arthritis and other inflammatory disease.
ISSN
0261-5614
Language
English
URI
http://hdl.handle.net/10371/68818
DOI
https://doi.org/10.1016/j.clnu.2007.07.008
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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