S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Apatite-mineralized polycaprolactone nanofibrous web as a bone tissue regeneration substrate.
- Yu, Hye-Sun; Jang, Jun-Hyeog; Kim, Tae-Il; Lee, Hae-Hyoung; Kim, Hae-Won
- Issue Date
- Journal of Biomedical Materials Research Part A, 2009;88A(3):747-754
- nanofiber substrate; electrospinning; apatite mineralization; bone regeneration matrix; osteoblast responses
- Degradable synthetic polymers with a nanofibrous
structure have shown great promise in populating
and recruiting cells for the reconstruction of damaged tissues.
However, poor cell affinity and lack of bioactivity
have limited their potential usefulness in bone regeneration.
We produced polymeric nanofiber poly(e-caprolactone)
(PCL) with its surface mineralized with bone-like apatite for
use as bone regenerative and tissue engineering matrices.
PCL was first electrospun into a nanofibrous web, and the
surface was further mineralized with apatite following a series
of solution treatments. The surface of the mineralized
PCL nanofiber was observed to be almost fully covered
with nanocrystalline apatites. Through mineralization, the
wettability of the nanofiber matrix was greatly improved.
Moreover, the murine-derived osteoblastic cells were
shown to attach and grow actively on the apatite-mineralized
nanofibrous substrate. In particular, the mineralized
PCL nanofibrous substrate significantly stimulated the
expression of bone-associated genes, including Runx2, collagen
type I, alkaline phosphatase, and osteocalcin, when
compared with the pure PCL nanofiber substrate without
mineralization. The currently developed polymer nanofibrous
web with the bioactive mineralized surface is considered
to be potentially useful as bone regenerative and tissue
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