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Transforming growth factor-alpha and oral fibroma: Immunohistochemical and in situ hybridization study.

Cited 6 time in Web of Science Cited 5 time in Scopus
Issue Date
2003
Publisher
Elsevier
Citation
J Oral Maxillofac Surg 61:1449-1454
Abstract
Purpose:
Transforming growth factor-α (TGF-α) is usually expressed in cell lines derived from sarcomas. It is known as a mitogen for fibroblasts. The aim of this study was to determine whether there were any differences in the expression pattern of TGF-α between normal oral mucosa and oral fibroma.

Patients and Methods:
Fourteen pathologic specimens (6 males and 8 females; 37.2 ± 23.2 years) and 10 normal oral mucosal specimens (5 females and 5 males; 43.8 ± 17.7 years) were used for this study. Identification of TGF-α was sought by using immunohistochemistry and in situ hybridization.

Results:
The samples from normal oral mucosa did not express TGF-α. One sample from oral fibroma did not express TGF-α (7.1%). Five samples from oral fibroma expressed TGF-α sparsely (35.7%). Eight samples showed diffuse expression of TGF-α (57.1%). The immunopositive reaction to TGF-α in oral fibroma was localized in the basal layer and the fibroblasts that resided beneath the epithelium. This pattern was also shown in the in situ hybridization study as well.

Conclusion:
TGF-α is expressed in oral fibromas. It suggested that TGF-α might play a role in fibroblast proliferation in oral fibromas.
ISSN
0304-3940
Language
English
URI
https://hdl.handle.net/10371/69632
DOI
https://doi.org/10.1016/j.joms.2003.02.001
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Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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