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Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury

Cited 30 time in Web of Science Cited 31 time in Scopus
Authors
Park, Chanhee; Cho, Ik-Hyun; Kim, Donghoon; Jo, Eun-Kyeong; Choi, Se-Young; Oh, Seog Bae; Park, Kyoungpyo; Kim, Joong Soo; Lee, Sung Joong
Issue Date
2008-01
Publisher
Elsevier
Citation
Neuroscience Letters 431 (2007) 123-128
Keywords
Toll-like receptor 2Heme oxygenase-1Glial activationStab-wound injury
Abstract
Traumatic brain injury is accompanied by glial cell activation around the site of the injury. In this study, we investigated the role of toll-like receptor 2 (TLR2) in glial cell activation using a stab-wound injury (SWI) model with TLR2 knock-out mice. Penetration of a normal mouse brain with a 26-G needle using a stereotaxic instrument resulted in an 18- and 4-fold upregulation of GFAP and CD11b mRNA, respectively, along the needle track in the injury area. However, in the TLR2 knock-out mice, the induced expression of these genes was reduced by 70% and 40%, respectively. Likewise, there was a reduction in the area of activated glial cells detected by immunohistochemistry and the glial cells had a less-activated morphology in the TLR2 knock-out mice. In addition, the expression of the heme oxygenase-1 (HO-1) gene, a glia-expressing wound-responsive gene, was reduced after SWI in TLR2 knock-out mice. Taken together, these data argue that TLR2 contributes to the glial cell activation and HO-1 gene expression associated with traumatic brain injury.
ISSN
0304-3940
Language
English
URI
https://hdl.handle.net/10371/69690
DOI
https://doi.org/10.1016/j.neulet.2007.11.057
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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