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"Immunoregulatory effects of extracts from the stem bark of Albizzia julibrissin Durazz
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- Authors
- Issue Date
- 2004-12
- Publisher
- Korean Acadamy of Oral Biology
- Citation
- International Journal of Oral Biology 29:137-144
- Keywords
- disease modifying anti-rheumatic(DMARD) ; albizzia julibrissin ; activated T cell ; apoptosis ; caspase-8
- Abstract
- Although there are many disease modifying antirheumatic drugs (DMARDs) available, more safe and effective reagents have yet to be developed. Activated T cells make good targets for DMARD therapy. Therefore, we screened over fifty herbal extracts, and identified that water extract from the stem bark of Albizzia julibrissin selectively killed activated T cells but not naive splenocytes, in vitro. Wb3-3, obtained by further extraction and column chromatography to maximize selective activity, was used for further investigation. Annexin-V and caspase activity assay revealed that WB3-3 killed activated T cells by inducing apoptosis, which was mediated through mainly caspase-8 rather than caspase-9. The effect of WB3-3 in vivo was conlirmed by the elimination of V8- but no V6-T cells following activation with Streptococcal Enterotoxin B (SEB). Furthermore, WB3-3 inhibited neither CD25 upregulationnor proliferative response, and rather increased IL-2 secretion during Con A activation of naive T cells.Our results imply the potential of WB3-3 to include a lead compound for a new immunoregulatory drug.
- ISSN
- 1226-7155
- Language
- English
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