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Characterization and in vivo evaluation of calcium phosphate coated cp-titanium by dip-spin method

Cited 18 time in Web of Science Cited 19 time in Scopus
Authors
Yeo, In-Sung; You, Changkook; Kim, Myung-Duk; Eom, Tae-Kwan; Lee, Jae-Yeol; Kim, Sukyoung
Issue Date
2005-12
Publisher
Elsevier
Citation
Current Applied Physics 5 (2005) 501-506
Keywords
Calcium metaphosphateSol–gelCoatingDegradationBiocompatibilityOsseointegration
Abstract
Calcium phosphate ceramics like hydroxyapatite (HA) and tricalcium phosphate (TCP) are good candidates for bone substitutes due to their chemical similarity to bone minerals. Additionally, the biodegradation property of bone substitutes may allow the organism to replace the foreign material by fully functional new bone in a balanced time schedule. Thus, the coating of biodegradable calcium phosphate ceramics on dental implants was conducted in this study to enhance the biocompatibility and eliminate the long-term adverse effects of HA coated implants. First, biodegradable calcium metaphosphate(CMP) sol was prepared and then coated on cp-Ti substrates by a dip-spin coating technique. The coated specimens were heat-treated at 600 for 6 h. CMP coated layer on cp-Ti was smooth and uniform with fine grains. It is observed that bone-to-implant contact area of CMP coated specimen at both 2 and 6 weeks was significantly higher than that of non-coated group. The biocompatibility and cytotoxicity of the CMP coated specimen were better than those of the non-coated specimen. Therefore, the CMP coating on cp-Ti is a good candidate for improving bone-to-implant osseointegration, although it is difficult to extrapolate in vitro results directly to in vivo situation.
ISSN
1567-1739
Language
English
URI
http://hdl.handle.net/10371/72046
DOI
https://doi.org/10.1016/j.cap.2005.01.020
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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