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Clinical Trial on Reversible Male Contraceptive With Long-Acting Sex Hormones : 성호르몬 병용에 의한 남성 가역성 수태조절법의 임상적 연구

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Authors

Lee, Hee Yong; Kim, Sang In; Kwon, E Hyock

Issue Date
1979-09
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.20 No.3, pp. 199-216
Abstract
In conclusion, for the development of an ideal
method of reversible male contraceptive using sex
hormones, a new combination with the lowest
dosage of Depo- Provera and Depo-Testosterone
should be developed by which full suppression
of spermatogenesis could be attained in a limited
period of time since occasional pregnancies had
been documented with the sperm counts of less
than 10 milliori/ml. The combined steroids
compounds used in this trial suppress sperm
production to azoospermia or severe oligospermia but could not achieve full suppression in all
subjects even when high doses of D-P plus
D- T were used. Full recovery of spermatogenesis
should be achieved in. all subjects following
cessation of drug administration. Any types
of side effects even transient loss of libido and
sexual potentia should not be occurred by the
drug administration in actually all age groups
of subjects who are treated. The maintenance
doses should be confirmed at which the subjects
remained consistently infertile during the drug
administration without any drug resistant
phenomenon.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/7218
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