융모성 성선 자극 호르몬이 자궁운동성에 미치는 영향

Abstract

In order to investigate the influence of human chorionic gonadotropin on the motility of nonpregnant uterus, 150 1. U. of HCG was injected intramuscularly to adult female rabbits and the intrauterine pressure was recorded prior to and after injection for 5 hours with time interval of 30 minutes or 1 hour. The animals were divided into two groups. They were; Group 1. Eleven rabbits with intact ovaries Group 2. Nine rabbits oophorectomized bilaterally. The intrauterine pressure generated by the contraction of the uterine musculature was recorded on the physiograph through the polyethylene tubing inserted in the uterine cavity which was surgically exposed. Through the tubing, constant flow of saline solution was secured by an infusion pump, and the pressure was transmitted to the pressure transducer via the liquid column. The area beneath the pressure curve in the recording paper represented the magnitude of the pressure impulse (integral) in finite period. The frequency of the uterine contraction was obtained by counting the number of waves in five minutes. The results obtained were as follows; 1. In the animals with intact ovaries. RCG resulted in the decrease of the intrauterine pressure impulse (integral) by 'l:l% and the frequency or contraction by 24% on the average, four hours· after injection. 2. In the bilaterally oophorectomized animals; the uterine responses to the RCG Were negligible. 3. It was suggested that exogenous HCG diminished the uterine motility via the alteration of ovarianfunction. 4. Both the impulse and the frequency of the' uterine contraction Were diminished, suggesting that no apparent inverse relationship resided het....een them.