S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 15 No.2 (1974)
만성 연탄가스 폭로가 백서의 임신에 미치는 영향에 관한 실험적 연구
An Experimental Study on the Effects of Chronic Briquette Gas Exposure to the Gestation Patterns of the Rats.
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.15 No.2, pp. 122-129
- Carbon monoxide poisoning is one of the most
prevalent noxious gas poisonings throughout world.
Especially high incidence of carbon monoxide poisoning
due to the use of the anthracite coal briquette
as the main domestic fuel has raised many
serious medical problems in Korea.
Author designed this study to observe the effects
of chronic exposure to relatively low concentration
of coal briquette gas on the gestation patterns of
Ninety rats divided into 3 groups. one for the
control. the other high concentration (CO, 1. 500
ppm, SO,. 5ppm) and the third low concentration
(CO, 750 ppm, S02, 2.5ppm) groups. The rats in
experimental group were exposed to briguette gas
30 minutes daily during the gestational period.
The pregnancy wastage. gestation rate by the
period. the size and body weight of the litters and
congenital amomalies of the litters were observed.
The findings obtained are as follows;
1. Higher incidence of pregnancy wastages was
found in the briquette gas exposure group compared
to the control group. The high concentration group
showed the highest rate of pregnancy wastages.
2. In the high concentration group. one-third of
the pregnancy wastage was obserbed at the end of
the 2nd week of the gestation and two-third of
them in the Srd week of the gestation.
3. The reduction in the size and the body weight
of the litters was "found in the gas exposure group
and this tendency was manifested in the high concentration
4. One case of ectromelia was observed in the
low concentration group and two cases in the high concentration group. The teratogenic effect of
hypoxia induced by carbon monoxide poisoning:
might be regarded as one of the factors in the genesis
of this type of congenital melformation.