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Changes in Histopathological and Serological Findings of the Liver after Treatment in Rabbit Clonorchiasis

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Authors
Hong, Sung-Tae; Huh, Sun; Kho, Weon-Gyu; Yu, Jae-Ran; Chai, Jong-Yil; Kim, Eui-Chong; Lee, Soon-Hyung
Issue Date
1990-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.31 No.2, pp. 117-127
Keywords
Clonorchis sinensisRabbitPraziquantelHistopathologyELISABiochemistryHematology
Abstract
In order to elucidate the recovery course and the residual change of clonorchiasis
after praziquantel treatment, the changing pattem of histopathological findings of the
liver, along with the serological, biochemical and hematological parameters, were evaluated
in experimental rabbit clonorchiasis. Twenty rabbits were infected each with 300 metacercariae
of Clonorchis sinensis and treated with praziquantel 200 mg/kg 14 weeks after infection.
Until one year after infection, a Widening of the bile ducts, proliferation of biliary
epithelium, and periductal fibrosis were observed in the liver, although the lesions became
much milder than those of the untreated rabbits. The levels of anti-e. sinensis IgG antibody
in the sera by EUSA decreased continuously after treatment. Biochemical items and hematological
parameters showed no consistent changing pattem after infection or after treatment. It
can be suggested that the histopathological lesions of rabbit cionorchlais, i.e., duct dilatation,
hyperplasia of biliary epithelium and periductal fibrosis, may be hardly reversible. However,
the level of circulating specific IgG antibody decreased significantly according to the healing
process of inflammation.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/7310
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 31 No.2 (1990)
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