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The Pathogenetic Role of Reactive Oxygen Species in Aminonucleoside Nephrosis

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Authors
Cheong, Hae Il; Choi, Yong; Ko, Kwang Wook; Shin, Mi Ja; Kim, Myung-suk
Issue Date
1994-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.35 No.2, pp. 105-111
Keywords
Puromycin aminonucleoside nephrosisAnionic siteReactive oxygen speciesXanthine oxidaseMalondialdehyde
Abstract
We studied the pathogenetic role of reactive oxygen species (ROS) in
rats with puromycin aminonucleoside nephrosis (PAN). Heavy albuminuria with markedly
decreased density of the anionic sites (AS) on glomerular basement membrane
(GBM) (2. 6 ± O. 98 compared to 20. 0 ± 1. 61 AS/l,OOOnm GBM in control) developed
7 days after PA injection. The malondialdehyde (MDA) levels in kidney
homogenates increased gradually (1. 16 ± O. 18 at day -1 to 1. 97 ± O. 23/g protein
at day 5). While catalase or dimethyl sulfoxide, administered with PA, did not affect the
course of PAN. superoxide dismutase and allopurinol reduced proteinuria
and decreased loss of the AS (11. 7 ± 2. 80 and 13, 7 ± 1. 27 AS/l.000nm GBM, reo
spectively) at day 7. These findings suggest that proteinuria in PAN results from the
loss of GBM AS. in which ROS generated by xanthine oxidase system plays an import.
ant role.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/7338
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 35 No.2 (1994)
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