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The Pathogenetic Role of Reactive Oxygen Species in Aminonucleoside Nephrosis
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- Authors
- Issue Date
- 1994-06
- Citation
- Seoul J Med, Vol.35 No.2, pp. 105-111
- Keywords
- Puromycin aminonucleoside nephrosis ; Anionic site ; Reactive oxygen species ; Xanthine oxidase ; Malondialdehyde
- Abstract
- We studied the pathogenetic role of reactive oxygen species (ROS) in
rats with puromycin aminonucleoside nephrosis (PAN). Heavy albuminuria with markedly
decreased density of the anionic sites (AS) on glomerular basement membrane
(GBM) (2. 6 ± O. 98 compared to 20. 0 ± 1. 61 AS/l,OOOnm GBM in control) developed
7 days after PA injection. The malondialdehyde (MDA) levels in kidney
homogenates increased gradually (1. 16 ± O. 18 at day -1 to 1. 97 ± O. 23/g protein
at day 5). While catalase or dimethyl sulfoxide, administered with PA, did not affect the
course of PAN. superoxide dismutase and allopurinol reduced proteinuria
and decreased loss of the AS (11. 7 ± 2. 80 and 13, 7 ± 1. 27 AS/l.000nm GBM, reo
spectively) at day 7. These findings suggest that proteinuria in PAN results from the
loss of GBM AS. in which ROS generated by xanthine oxidase system plays an import.
ant role.
- ISSN
- 0582-6802
- Language
- English
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