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An Immunohistochemical Study of the Expression of Adhesion Molecules in Gallbladder Lesions

Cited 34 time in Web of Science Cited 42 time in Scopus
Authors
Choi, Yoon-La; Xuan, Yan Hua; Shin, Young Kee; Chae, Seoung Wan; Kook, Myeong Cherl; Sung, Ro Hyun; Youn, Sei Jin; Choi, Jae Woon; Kim, Seok Hyung
Issue Date
2004-05
Publisher
Histochemical Society
Citation
J Histochem Cytochem; Vol.52, No.5; pp.591–601
Keywords
gallbladdercateninCD44CD44v6ICAM-1CD56CEAE-cadherinCD99immunohistochemistry
Abstract
We investigated the expression of 10 adhesion molecules (α-catenin, β-cate-nin, γ-catenin, CD44, CD44v6, ICAM-1, CD56, CEA, E-cadherin, and CD99) in 46 gallbladder carcinomas, 14 adenomas, 15 low-grade dysplasias, nine intestinal metaplasias, and 20 samples of normal gallbladder epithelium by immunohistochemistry. The expression of adhesion molecules was altered in gallbladder carcinomas and adenomas. In gallbladder carcinomas, increased expression of ICAM-1, CEA, and CD44v6 was observed, together with decreased expression of α/β/γ-catenin and CD99. In adenomas, aberrant expression of CD44v6 and CD56, as well as reduced expression of α/β/γ- and E-cadherins, was noted. Expression of α/β/γ-catenin was reduced in low-grade dysplasia, whereas there was no change in the expression of these adhesion molecules in metaplasia. Expression of ICAM-1, CD99, E-cadherin, and CD56 was correlated with clinical stage. In addition a correlation was noted between expression of ICAM-1 and E-cadherin and lymph node metastasis (p<0.05). These results suggest that altered expression of these adhesion molecules is involved in the progression and metastasis of gallbladder carcinomas.
ISSN
1551-5044(Online)
0022-1554(Print)
Language
English
URI
https://hdl.handle.net/10371/73477
DOI
https://doi.org/10.1177/002215540405200504
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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