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LMP1-Induced Downregulation of CD99 Molecules in Hodgkin and Reed-Sternberg Cells

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Authors
Lee, Im-Soon; Shin, Young Kee; Chung, Doo Hyun; Park, Seong Hoe
Issue Date
2001-08
Publisher
Informa Healthcare
Citation
Leuk Lymphoma; Vol.42(4); pp.587-594
Keywords
CD99LMP1NF-kappaBH-RS cellshodgkin's disease
Abstract
Hodgkin's and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkin's disease (HD). So far, several characteristics frequently seen in H-RS cells from different origins have been described, such as the high expression of Epstein-Barr virus latent membrane protein 1 (LMP1), the elevation of NF-kB activity, and the aberrant expression of molecules such as CD15, CD30, and CD99. Despite extensive studies on the nature of H-RS cells, the molecular mechanism by which H-RS cells are generated remained elusive. Recently, the forced down-regulation of CD99 was reported to induce typical H-RS phenotypes in vitro in a B cell line. Furthermore, it was revealed that LMP1 markedly reduces the CD99 expression at the transcriptional level. Since the presence of LMP1 is known to be associated with the H-RS cell formation, the data provide a possibility of linkage between LMP1 and HD via CD99, thus suggesting that, at least in part, the loss of CD99 may play a critical role in the pathogenic sequence to the formation of H-RS cells in HD. In this review, the role of CD99 in the generation of H-RS cells and its molecular mechanism will be suggested.
ISSN
1042-8194
Language
English
URI
https://hdl.handle.net/10371/73500
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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