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Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins

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Authors
Han, Seungnam; Nam, Jungyong; Li, Yan; Kim, Seho; Cho, Suk-Hee; Cho, Yi Sul; Choi, So-Yeon; Choi, Jeonghoon; Han, Kihoon; Kim, Youngrim; Na, Moonseok; Kim, Hyun; Bae, Yong Chul; Choi, Se-Young; Kim, Eunjoon
Issue Date
2010-11
Publisher
Society for Neuroscience
Citation
Journal of Neuroscience 30:15102-15112
Abstract
PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the
underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains
for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its
close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons
increases the density of dendritic spines and excitatory synapses in a manner that requires thePDZ(PSD-95/Dlg/ZO-1)-binding C termini
of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or
dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest
that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.
ISSN
0270-6474
Language
English
URI
http://hdl.handle.net/10371/74098
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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