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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans

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Authors
Jang, J. Y.; Park, E. K.; Ryoo, H. M.; Shin, H. I.; Kim, T. H.; Jang, J. S.; Park, H. S.; Choi, J. Y.; Kwon, T. G.
Issue Date
2010-11
Publisher
SAGE Publications
Citation
J Dent Res 89:1203-1207
Keywords
Matrilin-1mandibular prognathismpolymorphismSNP
Abstract
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19∼197.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05∼0.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03∼13.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism.
ISSN
0022-0345
Language
English
URI
https://hdl.handle.net/10371/74109
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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