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Tissue expression of manganese superoxide dismutase is a candidate prognostic marker for glioblastoma

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Authors
Park, Chul-Kee; Jung, Ji Hye; Moon, Min Jeong; Kim, Young-Yim; Kim, Jin Hyun; Park, Sung-Hye; Kim, Chae-Yong; Paek, Sun Ha; Kim, Dong Gyu; Jung, Hee-Won; Cho, Byung-Kyu
Issue Date
2009-07
Publisher
Karger
Citation
Oncology 2009;77:178-181
Keywords
ProteomicsLong-term survivalGlioblastomaPrognostic factorManganese superoxide dismutase
Abstract
Background: Characterization of a rare subgroup of glioblastoma
patients who survive for more than 3 years (longterm
survival glioblastoma, LTSGBL, patients) may be helpful
to identify prognostic factors. Materials and Methods: A
molecular-profiling proteomic approach using two-dimensional
gel electrophoresis (2-DE) and matrix-assisted la ser
desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS) were used to identify prognostic factors associated
with glioblastoma by comparing frozen tumor tissue
from LTSGBL patients with matched samples from shortterm
survival glioblastoma (STSGBL) patients. Western blot
(WB) analysis, reverse-transcriptase polymerase chain reaction
(RT-PCR) and immmunohistochemical (IHC) staining
were used for confirmation. Results: Among most candidate
spots identified by 2-DE, lack of overexpression of manganese
superoxide dismutase (MnSOD) in LTSGBL samples was
consistently observed using WB and RT-PCR. Conclusion: These results suggest that MnSOD expression level in tumor
tissue is a candidate marker for the prognosis of glioblastoma
patients.
ISSN
0030-2414
Language
English
URI
https://hdl.handle.net/10371/74201
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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