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A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation

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dc.contributor.authorKwon, Byoung S.-
dc.contributor.authorTan, Kong B.-
dc.contributor.authorNi, Jian-
dc.contributor.authorOh, Kwi-Ok-
dc.contributor.authorLee, Zang H-
dc.contributor.authorKim, Kack K.-
dc.contributor.authorKim, Young-J-
dc.contributor.authorWang, Sa-
dc.contributor.authorGentz, Reiner-
dc.contributor.authorYu, Guo-Liang-
dc.contributor.authorHarrop, Jeremy-
dc.contributor.authorLyn, Sally D.-
dc.contributor.authorSilverman, Carol-
dc.contributor.authorPorter, Terence G.-
dc.contributor.authorTruneh, Alem-
dc.contributor.authorYoung, Peter R.-
dc.date.accessioned2011-10-18T07:15:23Z-
dc.date.available2011-10-18T07:15:23Z-
dc.date.issued1997-05-
dc.identifier.citationJ. Bio. Chem. 272,14272-14276en
dc.identifier.issn0021-9258-
dc.identifier.urihttps://hdl.handle.net/10371/74287-
dc.description.abstractThe tumor necrosis factor receptor (TNFR) superfamily
consists of approximately 10 characterized members
of human proteins. We have identified a new member of
the TNFR superfamily, TR2, from a search of an expressed
sequence tag data base. cDNA cloning and
Northern blot hybridization demonstrated multiple
mRNA species, of which a 1.7-kilobase form was most
abundant. However, TR2 is encoded by a single gene
which, maps to chromosome 1p36.22–36.3, in the same
region as several other members of the TNFR superfamily.
The most abundant TR2 open reading frame encodes
a 283-amino acid single transmembrane protein with a
36-residue signal sequence, two perfect and two imperfect
TNFR-like cysteine-rich domains, and a short cytoplasmic
tail with some similarity to 4–1BB and CD40.
TR2 mRNA is expressed in multiple human tissues and
cell lines and shows a constitutive and relatively high
expression in peripheral blood T cells, B cells, and
monocytes. A TR2-Fc fusion protein inhibited a mixed
lymphocyte reaction-mediated proliferation suggesting
that the receptor and/or its ligand play a role in T cell
stimulation.
en
dc.description.sponsorshipThis work was supported by National Institutes of Health Grants AI 28175 and AR 40248 (to B. S. K.) and by a postdoctoral fellowship from the American Heart Association, Indiana Affiliate (to S. W.).en
dc.language.isoenen
dc.publisherAmerican Society for Biochemistry and Molecular Biologyen
dc.titleA Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activationen
dc.typeArticleen
dc.contributor.AlternativeAuthor오귀옥-
dc.contributor.AlternativeAuthor이장희-
dc.contributor.AlternativeAuthor김각균-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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