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Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress

Cited 16 time in Web of Science Cited 19 time in Scopus
Authors
Jeong, Eui Man; Kim, Chai-Wan; Jang, Gi-Yong; Cho, Sung-Yup; Shin, Dong-Myung; Kim, In-Gyu; Jeon, Ju-Hong
Issue Date
2009-02-18
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS; Vol.583 4; 648-654
Keywords
UbiquitinationProteasomal degradationOxidative stressTransglutaminase 2Calcium-overload
Abstract
Transglutaminase 2 (TG2) is a calcium-dependent enzyme that catalyzes the transamidation reaction. Conflicting pieces of evidence have been reported on the role of TG2 in apoptosis. In this report, we showed that TG2 increased in response to low level of oxidative stress, whereas TG2 diminished under high stress conditions. Monitoring TG2 expression, activity and calcium concentration in cells treated with A23187 revealed that the initial rise of calcium activates TG2 but subsequent calcium-overload induces degradation of TG2 via calcium-mediated polyubiquitination. These results indicate that the role of TG2 in apoptosis depends on the level of calcium influx triggered by oxidative stress. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
ISSN
0014-5793
Language
English
URI
https://hdl.handle.net/10371/76245
DOI
https://doi.org/10.1016/j.febslet.2009.01.032
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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