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CXCL10 and autoimmune diseases

Cited 156 time in Web of Science Cited 170 time in Scopus
Authors
Lee, Eun Young; Lee, Zang-Hee; Song, Yeong Wook
Issue Date
2009-03
Publisher
ELSEVIER SCIENCE BV
Citation
AUTOIMMUNITY REVIEWS; Vol.8 5; 379-383
Keywords
CXCL10Autoimmune diseaseSystemic lupus erythematosusRANKLRheumatoid arthritis
Abstract
CXCL10 is a 10 kDa protein, which is categorized functionally as a Th1-chemokine. It binds to the receptor CXCR3 and regulates immune responses through the activation and recruitment of leukocytes, such as, T cells, eosinophils, and monocytes. Recent reports have shown that serum and/or tissue expressions of CXCL10 are increased in various autoimmune diseases like rheumatoid arthritis (RA), systemic lupus rythematosus (SLE), Sjogren syndrome (SS), systemic sclerosis (SSc), and idiopathic inflammatory myopathy (IIM). Moreover, CXCL10 and CXCR3 may have important roles in leukocyte homing to inflamed tissues and in the perpetuation of inflammation, and therefore, tissue damage. Our recent study shows that CXCL10 also has a pathogenic role in bone destruction via receptor activator of NF-kappa B ligand (RANKL) induction in inflamed synovial tissue of RA. In addition to its chemotactic effect, CXCL10 may have pleiotropic functions. Further research on the function of this chemokine and interactions between CXCL10 and other cytokines and chemokines may provide therapeutic targets in various autoimmune diseases. (C) 2008 Elsevier B.V. All rights reserved.
ISSN
1568-9972
Language
English
URI
http://hdl.handle.net/10371/76345
DOI
https://doi.org/10.1016/j.autrev.2008.12.002
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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