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Enhanced interleukin-2 diphtheria toxin conjugate-induced growth suppression in retinoic acid-treated hypoxic hepatocellular carcinoma cells

Cited 2 time in Web of Science Cited 4 time in Scopus
Authors
Kim, Bo Hyun; Yoon, Jung-Hwan; Myung, Sun Jung; Lee, Jeong-Hoon; Lee, Soo-Mi; Lee, Hyo-Suk; Lee, Sung-Hee
Issue Date
2009-02-18
Publisher
ELSEVIER IRELAND LTD
Citation
CANCER LETTERS; Vol.274 2; 259-265
Keywords
HypoxiaRetinoic acidInterleukin-2Interleukin-2 diphteria toxin conjugateHepatocellular carcinoma
Abstract
Hypoxia induces survival signals in hepatocellular carcinoma (HCC). Hypoxia and retinoic acid (RA) may also induce interleukin-2 (IL-2) receptor expression, and thus we evaluated if RA and IL-2 receptor-targeted therapy are indicated in hypoxic HCCs. RA induced IL-2 receptor expression (R alpha, R beta, R gamma) in HCC cells, whereas hypoxia specifically induced IL-2 R gamma expression. IL-2 stimulated hypoxic HCC cell growth via p42/44 MAPK activation. Combination of denileukin diftitox and RA significantly suppressed hypoxic HCC cell growth compared to single agent-treated or normoxic cells. Therefore, denileukin diftitox and RA may be therapeutically implicated in infiltrative HCCs which are exposed to hypoxic environments. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN
0304-3835
Language
English
URI
https://hdl.handle.net/10371/76363
DOI
https://doi.org/10.1016/j.canlet.2008.09.025
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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