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Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from Actinidia arguta

Cited 15 time in Web of Science Cited 16 time in Scopus
Authors
Kim, Donghyun; Kim, Seon Hee; Park, Eun-Jin; Kim, Jiyoung; Kagawa, Junko; Jun, Kunisawa; Kim, Sunyoung; Kiyono, Hiroshi; Arai, Naoko; Cho, Sang-Heon
Issue Date
2009
Publisher
KARGER
Citation
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY; Vol.150 2; 164-171
Keywords
Actinidia argutaPG102MCP-1IL-10IL-6IgEFood allergyDiarrheaAntiallergy
Abstract
Background: Allergic reactions to food can involve diarrhea, vomiting, nausea and abnormal pain. PG102 has previously been shown to control various factors involved in allergy pathogenesis, including IgE and various Th1 and Th2 cytokines, in vivo as well as in vitro [Park EJ, et al.: J Allergy Clin Immunol 2005; 116: 1151-1157; Park EJ, et al.: J Invest Dermatol 2007; 127: 1154-1160]. These data indicate that PG102 might have antiallergic effects on allergic diarrhea. Here, we investigated whether PG102 could prevent allergic diarrhea in the murine ovalbumin (OVA)-induced allergic diarrhea model. Methods: BALB/c mice were orally treated with PG102, dexamethasone or water for 9 days on a daily basis, followed by subcutaneous injection with OVA on day 0. Animals were orally administrated with OVA from day 7, 3 times a week, over a period of approximately 20 days. Incidence of diarrhea, serum, OVA-restimulated splenocytes and lamina propria lymphocytes were analyzed. Results: Oral administration of PG102 could suppress the incidence of diarrhea in a murine allergic diarrhea model. The amelioration of allergic diarrhea by PG102 was accompanied with the inhibition of mast cell infiltration into the large intestine. The serum level of IgE, IL-6 and MCP-1 was decreased in PG102-treated mice. When splenocytes were isolated from respective groups and cultured in the presence of OVA, cells from PG102-administrated animals produced lesser amounts of IL-6 and MCP-1. Conclusions: PG102 has the potential to be used as a preventive for food allergic diseases. Copyright (C) 2009 S. Karger AG, Basel
ISSN
1018-2438
Language
English
URI
http://hdl.handle.net/10371/76373
DOI
https://doi.org/10.1159/000218119
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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