Browse

Genetic Polymorphisms of Hypoxia-Inducible Factor-1 Alpha and Cardiovascular Disease in Hemodialysis Patients

Cited 19 time in Web of Science Cited 18 time in Scopus
Authors
Zheng, Zhen Lon; Hwang, Young-Hwan; Kim, Seong Kyun; Kim, Sejoong; Ro, Han; Lee, Hyun Hee; Joo, Kwon Wook; Yang, Jaeseok; Chung, Woo Kyung; Sung, Su-Ah; Son, Min Jung
Issue Date
2009
Publisher
KARGER
Citation
NEPHRON CLINICAL PRACTICE; Vol.113 2; C104-C111
Keywords
HemodialysisHypoxia-inducible factor 1Single nucleotide polymorphism
Abstract
Background: Hemodialysis patients are prone to ischemic events potentially aggravated by hypoxia. The key player in adaptation to hypoxia is hypoxia-inducible factor-1 alpha (HIF-1 alpha). Therefore, we investigated the association of HIF-1 alpha polymorphisms with ischemia/hypoxia-related events in hemodialysis patients. Methods: Patients on maintenance hemodialysis were enrolled from 4 training hospitals in Korea. Seven single nucleotide polymorphisms (SNP) of HIF-1 alpha were genotyped. The association of these SNP with hypoxia-related clinical outcomes (ischemic diseases and anemia) and cancer was analyzed. Results: A total of 376 patients participated in the study. No significant difference in genotype distribution was found between subjects with and without the hypoxia-related events. Three sets of linkage disequilibrium blocks were made for haplotype analyses (rs2783778 and rs7148720 in 5` upstream region; rs7143164 and rs10873142; rs2301113, rs11549465 and rs2057482). Of these, the CT haplotype in the first set was associated with both acute myocardial infarction and frequent intradialytic hypotension (acute myocardial infarction: adjusted odds ratio = 0.15, 95% CI: 0.03-0.69; frequent intradialytic hypotension: adjusted odds ratio = 0.29, 95% CI: 0.12-0.72). Conclusion: Genetic polymorphisms of HIF-1 alpha were associated with acute myocardial infarction and intradialytic hypotension in hemodialysis patients. Copyright (C) 2009 S. Karger AG, Basel
ISSN
1660-2110
Language
English
URI
http://hdl.handle.net/10371/76380
DOI
https://doi.org/10.1159/000228542
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse