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Results of breast-conserving therapy for multifocal or multicentric breast cancers

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Authors
Chie, Eui Kyu; Kim, Kyubo; Han, Wonshik; Noh, Dong-Young; Im, Seock-Ah; Bang, Yung-Jue; Ha, Sung W.; Kim, Tae-You; Oh, Do-Youn
Issue Date
2009-09
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY; Vol.5 3; 200-205
Keywords
adjuvantbreast cancerradiotherapymutifocalmulticentricchemotherapy
Abstract
Aim: To evaluate the outcome of breast-conserving treatment including adjuvant radiotherapy in patients with multifocal or multicentric breast cancers. Methods: Between February 1996 and January 2002 13 patients presented with multifocal or multicentric breast tumors underwent breast-conserving therapy. Their median age was 44 years (range; 32-56). Nine patients had T1 disease and four had T2 disease. Nodal involvement was confirmed in three patients. All patients had breast-conserving surgery and axillary lymph node dissection with clear resection margin. Whole breast irradiation was given up to 50.4 Gy in 28 fractions followed by 10 Gy boost to tumor bed. Twelve patients received adjuvant systemic therapy: chemotherapy in four patients, hormonal therapy in five patients and both in three patients. Results: At a median follow-up duration of 70 months, all patients were alive without evidence of disease. The cosmetic outcome was evaluated in 11 patients. Cosmesis was excellent in two patients, good in six patients and fair in three patients. Conclusion: Multifocal and/or multicentric breast cancers can be successfully treated with breast-conserving surgery and adjuvant radiotherapy when complete microscopic resection and contemporary systemic therapy are given.
ISSN
1743-7555
Language
English
URI
http://hdl.handle.net/10371/76386
DOI
https://doi.org/10.1111/j.1743-7563.2009.01224.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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