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Comparison of risk factors and clinical responses to proton pump inhibitors in patients with erosive oesophagitis and non-erosive reflux disease

Cited 36 time in Web of Science Cited 39 time in Scopus
Authors
Lee, E. S.; Kim, N.; Lee, S. H.; Park, Y. S.; Jeong, S. H.; Jung, H. C.; Song, I. S.; Lee, D. H.; Kim, J. W.
Issue Date
2009-07-15
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
ALIMENTARY PHARMACOLOGY & THERAPEUTICS; Vol.30 2; 154-164
Abstract
P>Background There has been no report on the response to proton pump inhibitor (PPI) therapy and on-demand or the relapse rate of non-erosive reflux disease (NERD) and erosive oesophagitis in Korea. Aim To compare the risk factors, clinical symptoms and PPI responses between patients with erosive oesophagitis and NERD patients. Methods A survey was performed prospectively in the erosive oesophagitis (205 patients) and NERD group (200 patients). Clinical symptoms, risk factors and PPI responses were analysed. On-demand therapy and the relapse rate of GERD symptoms were investigated during a one-year follow-up. Results BMI >= 25 (OR 3.0, 95% CI 1.1-8.3), alcohol use (OR 2.9, 95% CI 1.0-8.3), hiatal hernia (OR 5.0, 95% CI 1.2-20) and triglyceride >= 150 mg/dL (OR 4.0, 95% CI 1.7-10) were more common in the erosive oesophagitis group than in the NERD group by multivariate analysis. The ratio of oesophageal to extra-oesophageal symptoms was higher in the erosive oesophagitis group compared with the NERD group (P < 0.001). The PPI response rates at 8 weeks were different (P = 0.02); refractory rates were higher in the NERD group (16.7%) compared with the erosive oesophagitis group (6.0%). However, there was no significant difference between the two groups in on-demand therapy or the relapse rate. Conclusion These results suggest that the underlying pathogenic mechanisms of erosive oesophagitis and NERD are distinct.
ISSN
0269-2813
Language
English
URI
https://hdl.handle.net/10371/76410
DOI
https://doi.org/10.1111/j.1365-2036.2009.04021.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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