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Improved Outcome of Adult Recipients with a High Model for End-Stage Liver Disease Score and a Small-For-Size Graft

Cited 52 time in Web of Science Cited 54 time in Scopus
Authors
Yi, Nam-Joon; Suh, Kyung-Suk; Lee, Hae Won; Shin, Woo Young; Kim, Won; Yoon, Jung-Hwan; Lee, Kuhn Uk; Lee, Hyo-Suk; Kim, Yoon Jun; Kim, Juhyun
Issue Date
2009-05
Publisher
JOHN WILEY & SONS INC
Citation
LIVER TRANSPLANTATION; Vol.15 5; 496-503
Abstract
Although adult-to-adult living donor liver transplantation (ALDLT) has shown comparable outcomes to deceased donor liver transplantation, the outcome of patients with a high MELD score (>25) and a small-for-size graft (SFSG<0.8% of graft-to-recipient weight ratio) is not known. For 7 years, 167 consecutive hepatitis B virus-infected recipients underwent ALDLT at our institution. Based on their MELD score without additional score for hepatocellular carcinoma (HCC), the recipients were divided into Group L (low MELD score, n = 105) or Group H (high MELD score, n = 62). To analyze the risk of the graft size, the patients were further stratified as follows: Group Hs (high MELD score and SFSG, n = 11), Hn (high MELD score and normal size graft, In 51), Ls (low MELD score and SFSG, In 18), and Ln (low MELD score and normal size graft, n = 87). The primary endpoint was one-year patient survival rate (1-YSR). The mean follow-up period was 32.6 months. The mean MELD scores were 17.1 in Group L and 32.6 in Group H. Group H had more patients with the complications of cirrhosis but less patients with HCC than Group L (p < 0.05). However, major morbidity rates and 1-YSR were similar in comparisons between Group L (46.7% and 86.7%) and H (59.7% and 83.8%) (p > 0.05). 1-YSR was similar among Group Hs (72.7%), Hn (86.3%), Ls (83.3%), and Ln (88.5%) groups (p = 0.278). The multivariate analysis revealed accompanying HCC and the year of transplant were risk factors for poor 1-YSR. However, 1-YSR without HCC patients was also similar in comparisons between group L (90.2%) and H (91.7%) (p = 0.847), and among Group Hs (80.0%), Hn (94.7%), Ls (72.7%), and Ln (96.7%) (p = 0.072). In conclusion, high MELD score (>25) didn`t predict 1-YSR in ALDLT. Improvement of the 1-YSR might be affected by center`s experience as well as the selection of patients with low risk of recurrence of HCC. Liver Transpl 15:496-503, 2009. (C) 2009 AASLD.
ISSN
1527-6465
Language
English
URI
http://hdl.handle.net/10371/76448
DOI
https://doi.org/10.1002/lt.21606
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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