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ATP Measurement Predicts Porcine Islet Transplantation Outcome in Nude Mice

Cited 22 time in Web of Science Cited 22 time in Scopus
Authors
Kim, Jae Hyeon; Park, Sang Gyu; Lee, Han Na; Lee, Yeon Yi; Kim, Hyong-Il; Kim, Sun Hee; Ha, Jongwon; Park, Kyong Soo; Kim, Sang Jun; Park, Chung-Gyu; Yu, Jae Eun; Park, Ho Sun
Issue Date
2009-01-27
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
TRANSPLANTATION; Vol.87 2; 166-169
Keywords
ATP contentDiabetic miceIslet qualityIslet assessment
Abstract
Current nude mice islet transplantation studies cannot be used prospectively. Therefore, to predict transplantation outcomes, reliable and rapid assays for islet quality assessment are warranted. This study evaluated the predictive power of the porcine islet ATP content on the outcomes of islet transplantation in nude mice. Here, we report that the ATP measurement using a small number of handpicked islets with a diameter of 100 to 150 gm is a good predictor of islet graft efficacy in nude mice. Using receiver-operator characteristic analysis, the area under the curve of the ATP content using a small number of handpicked islets was 0.867 (95% confidence interval 0.744-0.989, P<0.001). The sensitivity and the specificity measured were 83.3% and 73.3%, respectively. In conclusion, a simple and a rapid measurement of intraislet ATP content could be a promising substitute for current nude mice islet transplantation studies.
ISSN
0041-1337
Language
English
URI
http://hdl.handle.net/10371/76450
DOI
https://doi.org/10.1097/TP.0b013e318191e925
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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