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Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease

Cited 302 time in Web of Science Cited 318 time in Scopus
Authors
Lee, Jeong-Hoon; Kim, Donghee; Kim, Hwa Jung; Lee, Chang-Hoon; Kim, Won; Yoon, Jung-Hwan; Sung, Myung-Whun; Lee, Hyo-Suk; Cho, Sang-Heon; Kim, Yoon Jun; Yang, Jong In
Issue Date
2010-07
Publisher
ELSEVIER SCIENCE INC
Citation
DIGESTIVE AND LIVER DISEASE; Vol.42 7; 503-508
Keywords
Body mass indexFatty liverScreeningHepatic steatosis index
Abstract
Background/Aims: To optimize management of nonalcoholic fatty liver disease (NAFLD), a simple screening tool is necessary. In this study, we aimed to devise a simple index of NAFLD. Study: A cross-sectional study with 10,724 health check-up subjects (5362 cases with NAFLD versus age- and sex-matched controls) was conducted. Study subjects were randomly assigned to a derivation cohort or a validation cohort. Results: Multivariate analysis indicated that high serum alanine aminotransferase (ALT) to serum aspartate aminotransferase (AST) ratio, high body mass index (BMI), and diabetes mellitus were independent risk factors of NAFLD (all P<0.001). Using these variables, a formula was derived by a logistic regression model: hepatic steatosis index (HSI) = 8 x (ALT/AST ratio) + BMI (+2, if female; +2, if diabetes mellitus). HSI had an area under receiver-operating curve of 0.812 (95% confidence interval, 0.801-0.824). At values of <30.0 or >36.0, HSI ruled out NAFLD with a sensitivity of 93.1%, or detected NAFLD with a specificity of 92.4%, respectively. Of 2692 subjects with HSI <30.0 or >36.0 in the derivation cohort, 2305 (85.6%) were correctly classified. HSI was validated in the subsequent validation cohort. Conclusion: HSI is a simple, efficient screening tool for NAFLD that may be utilized for selecting individuals for liver ultrasonography and for determining the need for lifestyle modifications. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
ISSN
1590-8658
Language
English
URI
http://hdl.handle.net/10371/76487
DOI
https://doi.org/10.1016/j.dld.2009.08.002
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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