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Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus

Cited 8 time in Web of Science Cited 11 time in Scopus
Authors
Park, Sang Gyu; Park, Ho Seon; Jeong, In-Kyong; Cho, Young Min; Kang, Young-Sun; Park, Kyong Soo; Kim, Sunghoon; Lee, Hong Kyu
Issue Date
2010-06
Publisher
INFORMA HEALTHCARE
Citation
BIOMARKERS; Vol.15 4; 358-366
Keywords
Pancreasautoantibodyantisynthetase syndromeELISAautoimmune disease
Abstract
Objectives: To investigate whether or not antiaminoacyl-tRNA synthetase (aaRS) autoantibodies could be detected in patients with type 1 diabetes mellitus (DM) and be used as a diagnostic marker for type 1 DM, autoantibodies against aaRSs were measured in the plasma of normal subjects, patients with type 1 DM and patients with type 2 DM. Methods: An enzyme-linked immunosorbent assay was performed to detect anti-aaRS autoantibodies in the plasma of normal subjects, and patients with type 1 DM, and patients with type 2 DM. Results: From the 65 (normal), 58 (type 1 DM) and 57 (type 2 DM) subjects, anti-aaRS autoantibodies were found in 37.9% of patients with type 1 DM compared with 1.54% of the non-diabetic controls, and 5.26% of the patients with type 2 DM (p<0.0001). In addition, anti-aaRS autoantibodies were identified in 30% of patients with type 1 DM without classical type 1 DM autoantibodies. Conclusion: Anti-aaRS autoantibodies were identified in 37.9% of patients with type 1 DM. The results of this study demonstrate for the first time that autoantibodies against aaRSs are specifically associated with type 1 DM.
ISSN
1354-750X
Language
English
URI
https://hdl.handle.net/10371/76528
DOI
https://doi.org/10.3109/13547501003777823
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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