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Hepatitis A: Clinical Manifestations and Management

Cited 99 time in Web of Science Cited 106 time in Scopus
Authors
Jeong, Sook-Hyang; Lee, Hyo-Suk
Issue Date
2010
Publisher
KARGER
Citation
INTERVIROLOGY; Vol.53 1; 15-19
Keywords
Clinical manifestationPrognosisManagementHepatitis A virusKorea
Abstract
Due to improved living conditions and subsequent changes in hepatitis A epidemiology, the disease burden of hepatitis A is increasing in many regions. Recently, Korea has faced a large, community-wide outbreak of hepatitis A, which has prompted a vaccination program. The clinical spectrum of hepatitis A virus infection ranges from asymptomatic infection to fulminant hepatitis. Clinical manifestations depend on the age of the host: less than 30% of infected young children are symptomatic, while about 80% of infected adults manifest severe hepatitis with remarkably elevated serum aminotransferases. Fulminant hepatitis is rare, with a reported incidence from 0.015 to 0.5%. Atypical manifestations include relapsing hepatitis and prolonged cholestasis, and complicated cases with acute kidney injury have been reported. Extrahepatic manifestations, such as autoimmune hemolytic anemia, aplastic anemia, pure red cell aplasia, pleural or pericardial effusion, acute reactive arthritis, acute pancreatitis, acalculous cholecystitis, mononeuritis, and Guillain-Barre syndrome, have been rarely reported. Management of hepatitis A includes general supportive care, and critical decisions regarding liver transplantation await further studies on prognostic predictors. Fundamental management of hepatitis A is active vaccination. However, a vaccination program should be adapted to the regional situation, according to differing epidemiology and disease burden. Copyright (C) 2010 S. Karger AG, Basel
ISSN
0300-5526
Language
English
URI
https://hdl.handle.net/10371/76549
DOI
https://doi.org/10.1159/000252779
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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