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Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma

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Authors
Koh, Y-I.; Shim, J-U.; Lee, J-H.; Chung, I-J.; Rhee, J. H.; Chung, D. H.; Wi, J-O.; Lee, H. C.; Min, J-J.
Issue Date
2010-07
Publisher
WILEY-BLACKWELL
Citation
CLINICAL AND EXPERIMENTAL IMMUNOLOGY; Vol.161 1; 159-170
Keywords
airway inflammationnatural killer T cellsairway remodellingasthmaairway responsiveness
Abstract
P>Natural killer T (NK T) cells have been shown to play an essential role in the development of allergen-induced airway hyperresponsiveness (AHR) and/or airway inflammation in mouse models of acute asthma. Recently, NK T cells have been reported to be required for the development of AHR in a virus induced chronic asthma model. We investigated whether NK T cells were required for the development of allergen-induced AHR, airway inflammation and airway remodelling in a mouse model of chronic asthma. CD1d-/- mice that lack NK T cells were used for the experiments. In the chronic model, AHR, eosinophilic inflammation, remodelling characteristics including mucus metaplasia, subepithelial fibrosis and increased mass of the airway smooth muscle, T helper type 2 (Th2) immune response and immunoglobulin (Ig)E production were equally increased in both CD1d-/- mice and wild-type mice. However, in the acute model, AHR, eosinophilic inflammation, Th2 immune response and IgE production were significantly decreased in the CD1d-/- mice compared to wild-type. CD1d-dependent NK T cells may not be required for the development of allergen-induced AHR, eosinophilic airway inflammation and airway remodelling in chronic asthma model, although they play a role in the development of AHR and eosinophilic inflammation in acute asthma model.
ISSN
0009-9104
Language
English
URI
https://hdl.handle.net/10371/76654
DOI
https://doi.org/10.1111/j.1365-2249.2010.04151.x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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