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Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas

Cited 26 time in Web of Science Cited 28 time in Scopus
Issue Date
2010-06
Publisher
WILEY-BLACKWELL
Citation
NEUROPATHOLOGY; Vol.30 3; 224-231
Keywords
Cox-2gliomaprognostic factorSnailimmunohistochemistry
Abstract
The transcriptional factor Snail and enzyme cyclo-oxygenase-2 (Cox-2) are suggested to be important effectors of invasiveness and tumorigenesis in various tumors. Tumors of higher grade have the propensity for tumor cell migration and invasiveness. This study was performed in order to evaluate the association between Snail and Cox-2 expressions and their values as prognostic factors in various grades of glioma, Specimens of 56 patients with glioma were used in the study. Univariate analysis showed that WHO tumor grade, and expressions of Snail and Cox-2 were significant prognostic factors affecting overall and disease progression-free survival rates. In the multivariate analysis by Cox regression model, only WHO tumor grade was shown to be a significant independent prognostic factor of overall and progression-free survival rates. In conclusion, Snail and Cox-2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators.
ISSN
0919-6544
Language
English
URI
https://hdl.handle.net/10371/76666
DOI
https://doi.org/10.1111/j.1440-1789.2009.01072.x
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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