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Involvement of NF-κB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein

Cited 65 time in Web of Science Cited 73 time in Scopus
Authors
Kim, Su-Hyeong; Oh, Jung-Min; No, Jae-Hong; Bang, Yung-Jue; Juhnn, Yong-Sung; Song, Yong-Sang
Issue Date
2009-05
Publisher
OXFORD UNIV PRESS
Citation
Carcinogenesis, Vol.30 No.5, pp.753-757
Abstract
The human papillomavirus (HPV) E6 and E7 oncoproteins play important roles in cervical carcinogenesis through multiple mechanisms, including upregulation of cyclooxygenase-2 (COX-2), which has been shown to be involved in both carcinogenesis and cancer progression. To explore the role of E5 in cervical carcinogenesis, we herein investigated the effect of HPV 16 E5 on COX-2 expression. Our results revealed that E5 induced COX-2 expression through the epidermal growth factor receptor-signaling pathway, with nuclear factor-kappaB (NF-kappa B) and activator protein-1 (AP-1) acting as critical factors in E5-induced COX-2 expression. NF-kappa B inhibition blocked COX-2 expression more potently than inhibition of AP-1. Our findings collectively suggest that the HPV 16 E5 oncoprotein mediates cervical carcinogenesis at least in part via upregulation of COX-2 expression through NF-kappa B and AP-1, with NF-kappa B playing a larger role.
ISSN
0143-3334
Language
English
URI
http://hdl.handle.net/10371/76705
DOI
https://doi.org/10.1093/carcin/bgp066
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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