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Tissue Expression of Manganese Superoxide Dismutase Is a Candidate Prognostic Marker for Glioblastoma

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Park, Chul-Kee; Jung, Ji Hye; Moon, Min Jeong; Kim, Young-Yim; Park, Sung-Hye; Paek, Sun Ha; Jung, Hee-Won; Cho, Byung-Kyu; Kim, Dong Gyu; Kim, Chae-Yong; Kim, Jin Hyun
Issue Date
2009
Publisher
KARGER
Citation
ONCOLOGY; Vol.77 03월 04일; 178-181
Keywords
ProteomicsLong-term survivalManganese superoxide dismutasePrognostic factorGlioblastoma
Abstract
Background: Characterization of a rare subgroup of glioblastoma patients who survive for more than 3 years (long-term survival glioblastoma, LTSGBL, patients) may be helpful to identify prognostic factors. Materials and Methods: A molecular-profiling proteomic approach using two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used to identify prognostic factors associated with glioblastoma by comparing frozen tumor tissue from LTSGBL patients with matched samples from short-term survival glioblastoma (STSGBL) patients. Western blot (WB) analysis, reverse-transcriptase polymerase chain reaction (RT-PCR) and immmunohistochemical (IHC) staining were used for confirmation. Results: Among most candidate spots identified by 2-DE, lack of overexpression of manganese superoxide dismutase (MnSOD) in LTSGBL samples was consistently observed using WB and RT-PCR. Conclusion: These results suggest that MnSOD expression level in tumor tissue is a candidate marker for the prognosis of glioblastoma patients. Copyright (C) 2009 S. Karger AG, Basel
ISSN
0030-2414
Language
English
URI
https://hdl.handle.net/10371/76776
DOI
https://doi.org/10.1159/000231888
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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