Publications
Detailed Information
Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment
Cited 45 time in
Web of Science
Cited 50 time in Scopus
- Authors
- Issue Date
- 2010-12-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOCHEMICAL PHARMACOLOGY; Vol.80 12; 1930-1935
- Keywords
- Human papillomavirus ; COX-2 ; Cervical cancer ; EGFR ; E5
- Abstract
- Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation of cervical cells, inhibiting the tumor suppressors p53 and Rb. However, the role of E5 oncoprotein has been relatively less defined. HPV 16 E5 is a hydrophobic membrane-bound protein which associates with the Golgi apparatus, endoplasmic reticulum and perinuclear membrane. Accumulating evidences have suggested that E5 oncoprotein may also contribute to cervical carcinogenesis through modulating cellular signaling pathways in addition to augmenting the immortalization potential of E6 and E7. Multiple mechanisms, including activation of EGFR or inflammatory cell signaling pathway, have been implicated in malignant transformation by HPV 16 E5. Therefore, targeting E5 may be a rational approach for chemoprevention and treatment of cervical cancer, and understanding its oncogenic processes may help us to design novel therapeutic strategies. In this review, we discussed the roles of HPV 16 E5 in cervical carcinogenesis, altering several cellular signaling pathways involved in cell proliferation, angiogenesis and apoptosis. (C) 2010 Elsevier Inc. All rights reserved.
- ISSN
- 0006-2952
- Language
- English
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.