S-Space College of Medicine/School of Medicine (의과대학/대학원) Obstetrics & Gynecology (산부인과전공) Journal Papers (저널논문_산부인과학전공)
Analysis of the transforming growth factor β1 gene L509 C/T polymorphism in patients with advanced-stage endometriosis
- Kim, Jin Ju; Choi, Young Min; Choung, Seon Ha; Yoon, Sang Ho; Ku, Seung Yup; Moon, Shin Yong; Kim, Jung Gu; Lee, Kyu Sup
- Issue Date
- ELSEVIER SCIENCE INC
- FERTILITY AND STERILITY; Vol.93 7; 2121-2124
- Objective: To investigate whether the transforming growth factor beta (TGF-beta) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis. Design: Case-control study. Setting: University department of obstetrics and gynecology. Patient(s): Women with advanced-stage endometriosis (n = 485) and without endometriosis (n 352). Intervention(s): Genotyping by real-time polymerase chain reaction using a Taqman assay. Main Outcome Measure(s): Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-beta 1 gene. Result(s): The genotype distribution of the TGF-beta 1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group. Conclusion(s): These results suggest that the TGF-beta 1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis. (Fertil Steril (R) 2010;93:2121-4. (C)2010 by American Society for Reproductive Medicine.)
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