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Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria

Cited 22 time in Web of Science Cited 23 time in Scopus
Authors
Lee, Jung Eun; Park, Hansoo; Ju, Young Seok; Kwak, Minhye; Oh, Ha Young; Seo, Jeong-Sun; Kim, Jong-Il
Issue Date
2009-04-30
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 4; 253-258
Keywords
albuminuriaoxidative phosphorylationcardiovascular diseasesDNA, mitochondrialmitochondria
Abstract
It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondriall DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
ISSN
1226-3613
Language
English
URI
https://hdl.handle.net/10371/76855
DOI
https://doi.org/10.3858/emm.2009.41.4.028
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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