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Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria
Cited 26 time in
Web of Science
Cited 28 time in Scopus
- Authors
- Issue Date
- 2009-04-30
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE; Vol.41 4; 253-258
- Keywords
- albuminuria ; oxidative phosphorylation ; cardiovascular diseases ; DNA, mitochondrial ; mitochondria
- Abstract
- It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondriall DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P = 0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P = 0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P = 0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
- ISSN
- 1226-3613
- Language
- English
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