신경 활동에 따른 반사율 변화를 이용한 광섬유 기반의 신경 신호 검출

Abstract

Electrodes, one of the most widely used method for neural recording, have the drawback in their long-term reliability. The electrode implanted into the brain frequently stops working when reactive responses of brain tissues induce a fibrous and cellular sheath encapsulating the conductor surface of the electrode. As a new chronic neural recording technique, this study suggests an optical neural probe. We have built a fiber-based system to monitor changes in the reflectance of a brain tissue during neural activation. As the result, we found a concurrent optical change with the electrical response (population spike) in rat hippocampal slices. This finding will be applied to realization of the chronic optical neural probe.: [203]