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Cancer incidence among paraquat-exposed pesticide applicators in the Agricultural Health Study

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Authors
Park, Sue K.; Kang, Daehee; Beane-Freeman, Laura; Blair, Aaron; Sandler, Dale P.; Knott, Charles; Alavanja, Michael; Gwak, Jin; Lynch, Charles F.; Hoppin, Jane A.
Issue Date
2009-09
Publisher
ABEL PUBLICATION SERVICES
Citation
INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH; Vol.15 3; 274-281
Keywords
ParaquatAgricultural Health Studycancer incidencenon-Hodgkin`s lymphoma
Abstract
Paraquat (1,1`-dimethyl-4, 4`-bipyridinium dichloride) is a nonselective herbicide that is extremely toxic after acute exposure. It was once widely used in North America and is still used in some countries, including the United States. Although there is little firm evidence that paraquat is a carcinogen, previous Studies have suggested a potential relationship with some cancers. This prospective cohort Study was performed to evaluate the association between lifetime paraquat exposure and cancer incidence among licensed pesticide applicators with 9.1 years of median follow-up. The lifetime ever-use of paraquat was evaluated in 56,224 subjects at baseline and exposure-response relationship was evaluated in 24,667 subjects (44%) who provided detailed information on total life-time paraquat exposure in a second questionnaire. Among the total subjects, the risk for non-Hodgkin`s lymphoma (NHL) in the exposed group was marginally elevated (Relative risk [RR], 1.47; 95% confidence interval [CI], 0.97-2.23) compared to the non-exposed group. However, among the 24,667 applicators who Supplied total life-time exposure days, the highest tertile of lifetime exposure-days (LE) and intensity-weighted lifetime exposure-days (IWLE) was not significantly associated with NHL risk (RR, 1.57; 95%CI, 0.57-4.23 for LE; RR, 1.42; 95%CI, 0.40-4.71 for IWLE, respectively) and there was no significant exposure-response trend (p-trend > 0.1). There was Some suggestion of a possible link between paraquat exposure and NHL risk in humans, but die inconsistency in exposure level trend suggests that this could be a chance finding.
ISSN
1077-3525
Language
English
URI
https://hdl.handle.net/10371/76924
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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