S-Space College of Medicine/School of Medicine (의과대학/대학원) Microbiology (미생물학전공) Journal Papers (저널논문_미생물학전공)
High-dose cyclophosphamide-mediated anti-tumor effects by the superior expansion of CD44(high) cells after their selective depletion
Cited 8 time in Web of Science Cited 8 time in Scopus
- Issue Date
- ELSEVIER GMBH, URBAN & FISCHER VERLAG
- IMMUNOBIOLOGY; Vol.215 3; 182-193
- Anti-tumor effects ; Regulatory T cell ; Memory T cell ; IL-15/IL-15R ; Cyclophosphamide
- As alkylating agents, cyclophosphamides (CTX) are used to treat various cancers and, ironically, to boost immune responses. In the present study, we attempted to elucidate the mechanism responsible for the immunomodulatory effect of high-dose CTX in an established tumor model. A single injection of high-dose CTX increased the survival rate of immunocompetent, but not immunodeficient, mice. Notably, 10 days after CTX injection, the number of CD44(high) memory T cells significantly increased, without a selective decrease in the actual number and percentage of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). However, the proportion of Tregs among CD4(+) T cells decreased due to expansion of memory and other CD4+ T cell subtypes. This outcome was accompanied by an increase in IL-15 mRNA and up-regulation of IL-15 receptors in the CD44(+)CD8(+) T cell compartment. We postulate that the CTX-induced change in T cell balance may increase anti-tumor immunity. (C) 2009 Elsevier GmbH. All rights reserved.
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