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Soluble pig lymphocyte activation gene-3 (LAG-3; CD223) inhibits human-to-pig xenogeneic mixed lymphocyte reaction
DC Field | Value | Language |
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dc.contributor.author | Kim, Seon-Soo | - |
dc.contributor.author | Byun, Hyun-Jung | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Lee, Han-Hyoung | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Chun, Taehoon | - |
dc.contributor.author | Park, Chung-Gyu | - |
dc.contributor.author | Lee, Suk Jun | - |
dc.date.accessioned | 2012-06-11T02:07:27Z | - |
dc.date.available | 2012-06-11T02:07:27Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | BIOTECHNOLOGY LETTERS; Vol.32 2; 203-208 | ko_KR |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76941 | - |
dc.description.abstract | Lymphocyte activation gene-3 (LAG-3; CD223) is a transmembrane protein that is structurally similar to CD4. Since LAG-3 has a much higher binding affinity to MHC class II than that of CD4, several approaches using soluble LAG-3 were used to modulate immune responses by activation or inhibition of MHC class II expressing antigen presenting cells. In this study, we constructed soluble pig LAG-3 containing a critical binding site (D1 and D2 region) to MHC class II molecules, combined with a constant region of an immunoglobulin (Ig) heavy chain. Flow cytometry analyses indicated that soluble pig LAG-3 binds to both pig and human MHC class II molecules. Moreover, soluble pig LAG-3 can inhibit human lymphocyte proliferation in the human-pig xenogeneic mixed lymphocyte reaction in a dose-dependent manner. These results indicate that soluble pig LAG-3 may be useful for controlling the xenogeneic T cell immune responses between the human and pig. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER | ko_KR |
dc.subject | Co-receptor | ko_KR |
dc.subject | Lymphocyte activation gene-3 | ko_KR |
dc.subject | Mixed lymphocyte reaction | ko_KR |
dc.subject | Xenogeneic response | ko_KR |
dc.subject | T cell activation | ko_KR |
dc.subject | Pig | ko_KR |
dc.title | Soluble pig lymphocyte activation gene-3 (LAG-3; CD223) inhibits human-to-pig xenogeneic mixed lymphocyte reaction | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김선수 | - |
dc.contributor.AlternativeAuthor | 변현정 | - |
dc.contributor.AlternativeAuthor | 김상훈 | - |
dc.contributor.AlternativeAuthor | 이한형 | - |
dc.contributor.AlternativeAuthor | 이석준 | - |
dc.contributor.AlternativeAuthor | 김상준 | - |
dc.contributor.AlternativeAuthor | 박청규 | - |
dc.contributor.AlternativeAuthor | 전태훈 | - |
dc.identifier.doi | 10.1007/s10529-009-0144-9 | - |
dc.citation.journaltitle | BIOTECHNOLOGY LETTERS | - |
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dc.description.tc | 2 | - |
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