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Expression of neuronal antigens and related ventral and dorsal proteins in the normal spinal cord and a surgically induced open neural tube defect of the spine in chick embryos: an immunohistochemical study

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Authors
Lee, Do-Hun; Phi, Ji Hoon; Chung, You-Nam; Lee, Yun-Jin; Cho, Byung-Kyu; Park, Moon-Sik; Wang, Kyu-Chang; Kim, Dong Won; Kim, Seung-Ki
Issue Date
2010-05
Publisher
SPRINGER
Citation
CHILDS NERVOUS SYSTEM; Vol.26 5; 627-636
Keywords
Spinal cordChick embryoVentral and dorsal markersNeuronOpen neural tube defect
Abstract
The aims of this study were to elucidate the processes of neuronal differentiation and ventrodorsal patterning in the spinal cord of the chick embryo from embryonic day (E) 3 to E17 and to study the effect of a prenatal spinal open neural tube defect (ONTD) on these processes. Expression patterns of neuronal antigens (neuronal nuclear antigen, neurofilament-associated protein (NAP), and synaptophysin) and related ventral markers [sonic hedgehog, paired box gene (PAX)6, and islet-1], and dorsal markers (bone morphogenetic protein, Notch homolog 1, and PAX7) were investigated in the normal spinal cord and in a surgically induced spinal ONTD in chick embryos. Four normal and ONTD chick embryos were used for each antigen group. There were no differences in the expression of neuronal and ventrodorsal markers between the control and ONTD groups. NAP and synaptophysin were useful for identifying dorsal structures in the distorted anatomy of the ONTD chicks.
ISSN
0256-7040
Language
English
URI
http://hdl.handle.net/10371/77062
DOI
https://doi.org/10.1007/s00381-009-1049-6
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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