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전립샘암의 병인
Pathogenesis of Prostate Cancer

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Authors
윤철용; 변석수
Issue Date
2010-02
Publisher
KOREAN MEDICAL ASSOC
Citation
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION; Vol.53 2; 98-106
Keywords
Prostate cancerEpigeneticsPathogenesisGene전립샘암병인유전자후성학
Abstract
Prostate cancer is one of the most frequent cancers in Western countries and has been also one of the most rapidly increasing malignant diseases in Korean men. This disease shows diverse features in clinical course ranging from an indolent disease to a lethal one. Accordingly, underlying molecular mechanisms and genetic changes involved in the development and progression of various types of prostate cancer are very heterogeneous. Thus, investigation of pathogenesis of prostate cancer is very challenging, and, at this point of time, only a handful of molecular and genetic factors were identified as pathogenic factors for prostate cancer. Plenty of data support the strong relationship between age, race and family history and the development of prostate cancer. In addition, androgen related factors such as androgen metabolism and receptor signaling are highly correlated with tumor development and progression. Numerous genetic or epigenetic changes including gene mutation and methylation contribute to the development and progression of prostate cancer. In this article, we summarize the current understanding of the pathogenesis of prostate cancer, with a special focus on underlying genetic and epigenetic alterations.
ISSN
1975-8456
Language
Korean
URI
http://hdl.handle.net/10371/77082
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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